tamarind – skill Thiết kế & UI cho agent AI

Tamarind Bio

Tamarind runs molecular-design and structural-biology tools on managed compute:

structure prediction, protein and antibody design, docking, binding-affinity

prediction, MSA generation, and molecular dynamics. Use it when the user requests

Tamarind, its REST API/MCP server, or cloud execution of these scientific tools.

For local sequence processing or molecular descriptors, use a local library.

Sources and review scope

The REST contracts and public catalog were reviewed on 2026-09-30. Examples are

illustrative until validated against the user's account; this review did not run

authenticated jobs or establish scientific accuracy for any model.

• [API index](https://app.tamarind.bio/llms.txt) and

[complete guide](https://app.tamarind.bio/llms-full.txt).

• [Current OpenAPI](https://app.tamarind.bio/api/openapi.json) includes discovery,

validation, jobs, files, and newer pipeline/custom-tool surfaces.

[openapi.yaml](https://app.tamarind.bio/openapi.yaml) is also available. Check that

needed paths exist: the merged spec can return HTTP 200 with only its classic

surface when the backend spec cannot be fetched.

• [Public catalog](https://app.tamarind.bio/tools.json) needs no key; query ?type=

or ?tag=. It documents public tools and conditional required settings, not

every optional parameter or account entitlement.

• [Product documentation index](https://docs.tamarind.bio/llms.txt) links to

Markdown pages, including the [MCP guide](https://docs.tamarind.bio/tamarind/mcp-server.md).

Fetch the account's current schemas before composing a run. Where the prose guide

and OpenAPI differ, prefer the operation/schema for field shapes, and record any

unresolved difference rather than guessing.

Access

1. Use the user's Tamarind deployment. The shared base is

https://app.tamarind.bio/api; a dedicated organization deployment has its own

host and account data. Every relative REST path below is under /api.

2. Obtain a key from the deployment's API settings and read it from

TAMARIND_API_KEY; send it as x-api-key. Keep keys out of files and logs.

3. Check the account's current allowance and compute budget before scaling up.

Free usage is a monthly allowance, not an unconditional promise of ten jobs

forever; billing and entitlements can change.

# Public discovery requires no credential.
curl --fail-with-body 'https://app.tamarind.bio/tools.json?type=alphafold'
# Account-scoped discovery:
curl --fail-with-body 'https://app.tamarind.bio/api/tools' \
  -H "x-api-key: $TAMARIND_API_KEY"

For REST examples install requests in the execution environment. The official

CLI distribution is tamarind-cli, and its Custom Tools Python client imports

as from tamarind import Tamarind; the unrelated package named tamarind is not

this client. See the [SDK reference](https://app.tamarind.bio/api-docs/custom-tools-sdk-reference).

Core job recipes below use HTTP directly.

Workflow

1. Discover. Read GET /tools and match the user's scientific task to the tool

description. Built-ins return an array; ?custom=true lists legacy custom

tools only. Current custom deployments can be missing from this list: use the

known deployed name and its schema before concluding that it is unavailable.

2. Read the schema. GET /tools/{name}/schema returns a JSON Schema for the

settings object. GET /tools also supplies a trimmed settings parameter

list. Check task-dependent fields, file extensions, list values, and defaults.

3. Validate. Send POST /validate-job with type, settings, and optional

jobName. Check HTTP status first, then JSON valid. On success, inspect and

use normalized as the settings to submit. Address unrecognized_settings

if returned, even alongside valid: true: an optional-field typo can otherwise

silently leave the default in effect. Validation checks fields, not all submit

policies, queue limits, or deployment readiness.

4. Submit once. POST /submit-job takes jobName, type, settings, optional

version for a custom-tool build, and optional/organization-required

projectTag. Persist the submitted name and settings. A successful response

is plain text, not a JSON receipt. Use the returned stored name.

5. Poll. GET /jobs?jobName=... returns a row directly. Single-job terminal

states are Complete, Stopped, and Failed; handle legacy Deleted or an

exact-lookup error without looping indefinitely. Poll batch parents using

batchStatus, and poll newer pipelines on their own run endpoint.

6. Download and inspect. POST /result returns a JSON string URL on 200,

or 202 with status: "preparing". Retry result retrieval after 202, without

resubmitting compute. GET the signed URL without the Tamarind API-key header.

Download the archive only for successful runs; request fileName: "output.log"

for stopped/failed jobs. Verify the scientific outputs after downloading.

[Workflow recipes](references/workflows.md) implement validation, stored names,

bounded polling, 202 handling, batch validation, and pagination. They are locally

smoke-tested with simulated responses; authenticated execution remains untested.

Picking tools and interpreting results

Select by inputs, intended output, and modeling assumptions, then confirm the

candidate in the live catalog. These are anchors, not a guaranteed catalog:

| Task | Candidates and decisions |

|---|---|

| Protein/complex structure | alphafold for AF2 monomers/multimers; boltz, chai, or protenix for cofolding including ligands/nucleic acids; esmfold for fast single-sequence protein folding. Check esmfold2 separately: its current catalog includes protein, DNA, RNA, and ligand complexes. |

| Binder/motif design | bindcraft, boltzgen, rfdiffusion; choose by target type, scaffold constraints, and required structure inputs. |

| Inverse folding | proteinmpnn/ligandmpnn consume structures and design sequences. Re-fold designs and compare to the intended backbone/interface. |

| Small-molecule docking | autodock-vina for a fixed receptor and search box; diffdock for diffusion docking; boltz/chai for cofolding. Choose the modeling approach for the task, not to avoid supplying a required input. |

| Antibody/developability/MSA/MD | Filter descriptions and schemas for the specific task; availability and inputs differ by tool. |

Confidence scores describe model confidence, not experimental binding, specificity,

or affinity. Compare designed backbones, interfaces, clashes, chain/residue mapping,

and developability. Check ligand chemistry and stereochemistry; docking scores

are not interchangeable with measured binding free energies. Record tool/model,

input provenance, chain mapping, seeds/samples, MSA/template choices, normalized

settings, and any user-selected filtering thresholds.

Honor the user's selected tool and budget. Use authorized defaults for routine

choices; surface unresolved choices that materially affect the scientific task or

compute scope before a large campaign. Never silently substitute a different

scientific task because its inputs are easier to supply.

File inputs and chaining

• Upload a structure with PUT /upload/{filename} (binary body; follow the

documented redirect), then reference the registered relative name, e.g.

target.pdb or inputs/target.pdb when ?folder=inputs was used.

• Confirm names using GET /files; it returns a non-paginated array for the

selected folder, not a list of a job's outputs.

• Prefer these paths over inline file content. The current guide says redundant

account-email prefixes are stripped; there is no longer a universal

double-prefix failure. Arbitrary strings are not necessarily file references.

• Reuse a completed job's file as JobName/path/to/file.ext, matching the next

parameter's supported extensions and list/scalar shape. Do not guess filenames.

• ProteinMPNN designs must feed a folding tool's sequence field. A structural

template field does not mean "fold this designed sequence". Read generated

FASTA/CSV sequences and validate one folding settings object per sequence.

• Do not author internal fields such as submit_method, msa, or monomer_msa.

Batches and pipelines

POST /submit-batch accepts one type, a nonempty settings array, batchName,

and optional parallel jobNames. Validate every row using array-mode

/validate-job (up to 1,000 rows per call), and use each row's normalized settings.

Submission allows up to 30,000 expanded jobs, counting design fan-out, and

has a separate approximately 4.5 MB request limit. Split on both constraints.

Do not assume old weightedHoursBudget, maxRuntimeSeconds, or gpuType request

fields enforce a cap: they are absent from the current batch schema. Use confirmed

account controls and an agreed job/sample count.

Poll `GET /jobs?jobN

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